header
Image from OpenLibrary

Study of the relation between single nucleotide polymorphisms of Forkhead Box gene (FOX) and hepatocellular carcinoma in Egyptian patients / Mira Magdy William Ayad ; Supervised Tarek Mohamed Kamal Motawi , Atef Tadros Fahim , Dina Sabry Abdelfatah

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mira Magdy William Ayad , 2022Description: 133 P . : charts , maps ; 25cmOther title:
  • دراسة علاقة التعدد الجيني الفردي للنيوكليوتيد لجين فوركهيد بوكس بسرطان الكبد في المرضى المصريين [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of biochemistry Summary: Hepatocellular carcinoma (HCC) constitutes a challenging health problem in Egypt due to high incidence of hepatitis C virus (HCV) infection. HCC is characterized by genetic heterogeneity that may arise from alterations at multiple genes. The transcription factor forkhead box P1 (FOXP1) has been implicated in cellular proliferation, differentiation, metabolism and longevity as well as hepatic tumorigenesis. The present study was designed to explore the association of C/A rs2687201 and C/T rs2121783 single nucleotide polymorphisms (SNPs) in FOXP1 gene with HCC susceptibility, gene expression and protein level as well as overall survival in HCV Egyptian patients. The study included 194 Egyptian patients comprising 86 patients diagnosed with HCV infection and 108 patients with HCV-related HCC in addition to 80 volunteers as controls.SNPs were studied using allelic discrimination while qRT-PCR and ELISA were performed to assess FOXP1 gene expression and protein level, respectively. The current results revealed a significant association between FOXP1 rs2687201 and HCC risk evidenced by higher A allele and (CA+AA) genotype frequencies in HCC patients compared to HCV patients and controls in a dominant model. In addition, FOXP1 rs2121783 was significantly associated with HCC risk evidenced by higher T allele and TT genotype frequencies in HCC patients in comparison with HCV patients and controls in a recessive model. However, no such association was found when comparing HCV patients to controls
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.Ph.D.2022.Mi.S (Browse shelf(Opens below)) Not for loan 01010110085584000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.Ph.D.2022.Mi.S (Browse shelf(Opens below)) 85584.CD Not for loan 01020110085584000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of biochemistry

Hepatocellular carcinoma (HCC) constitutes a challenging health problem in Egypt due to high incidence of hepatitis C virus (HCV) infection. HCC is characterized by genetic heterogeneity that may arise from alterations at multiple genes. The transcription factor forkhead box P1 (FOXP1) has been implicated in cellular proliferation, differentiation, metabolism and longevity as well as hepatic tumorigenesis. The present study was designed to explore the association of C/A rs2687201 and C/T rs2121783 single nucleotide polymorphisms (SNPs) in FOXP1 gene with HCC susceptibility, gene expression and protein level as well as overall survival in HCV Egyptian patients. The study included 194 Egyptian patients comprising 86 patients diagnosed with HCV infection and 108 patients with HCV-related HCC in addition to 80 volunteers as controls.SNPs were studied using allelic discrimination while qRT-PCR and ELISA were performed to assess FOXP1 gene expression and protein level, respectively. The current results revealed a significant association between FOXP1 rs2687201 and HCC risk evidenced by higher A allele and (CA+AA) genotype frequencies in HCC patients compared to HCV patients and controls in a dominant model. In addition, FOXP1 rs2121783 was significantly associated with HCC risk evidenced by higher T allele and TT genotype frequencies in HCC patients in comparison with HCV patients and controls in a recessive model. However, no such association was found when comparing HCV patients to controls

Issued also as CD

There are no comments on this title.

to post a comment.