Recent advances in hereditary epidermolysis bullosa : a review of literature / Shereen Adel Ali Ahmed ; supervised Mohammad Maged Yehia ElBatawi , Naglaa Nabil Radwan , Rehab Mohammad Sobhi

Thesis (M.Sc.) - Cairo University - Faculty Of Medicine - Department Of Dermatology and Venerology

Epidermolysis bullosa (EB) is a group of inherited bullous disorders characterized by blister formation in response to mechanical trauma , with varying degrees of severityThe dermal - epidermal junction of the skin is a vital area of attachmentny defects in this junction would lead to fragility of the skinEB is traditionally classified into three major categories : EB simplex , junctional EB , and dystrophic EBIn addition , a new category termed hemidesmosomal EB is describedThere are different classification schemes for EBThe different forms of EB have been linked to mutations in no less than ten genes encoding the major basement membrane zone proteinsEB can be diagnosed both postnatally and prenatally with the recent advances in molecular diagnosisCurrent treatment of EB revolves around supportive care and prevention of complicationsPotential future therapies for EB include protein and gene therapies

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