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Immunobiological activity of synthetic peptides from schistosoma mansoni glyceraldehyde - 3 - phosphate dehydrogenase / Mona Hassan Farouk Montash ; supervised Victorine Bishara , Rashika ElRidi , Gamil Amin

By: Contributor(s): Language: Eng Publication details: Cairo : Mona Hassan Farouk Montash , 2004Description: 126 Leaves : ill ; 30cmOther title:
  • النشاط المناعي - البيولوجى للبيبتيدات المصنعة من انزيم جلسرالدهايد 3 - فوسفات ديهايدروجينا لدودة بلهارسيا المستقيم [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty Of Science - Department Of Biochemistry Summary: SG3PDH is a candidate vaccine for human schistosomiasisSix synthetic peptides were selected based on lowest homology to the human enzyme and named A , B1 , B , C , D and EImmunization of BALB / c mice with peptide A , B , C or E inducedweak cellular and humoral immune responses , whereas immunization with peptide B1 or D elicited strong immune responses that were protective to the challenge worms , not the hostTetrameric constructs containing 2 copies of 2 different peptides (D - MAP) greatly increased the immunogenicity of the peptides , Anti - D - MAP A - B immune responses were associated with significant (P < 005) decrease in worm and egg burdenD - MAP B1 - C caused no significant changes in challenge worm parametersImmunization with D - MAP D - E elicited increase in the challenge worm burden and decrease in worm fertilityThese results were discussed in relation to the variability in the nature and outcome of immune responses for each SG3PDH - derived peptide , and the neutralization of their often opposing effects in the D - MAP construct
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.02.M.Sc.2004.Mo.I. (Browse shelf(Opens below)) Not for loan 01010110043455000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.02.M.Sc.2004.Mo.I. (Browse shelf(Opens below)) Not for loan 01020110043455000

Thesis (M.Sc.) - Cairo University - Faculty Of Science - Department Of Biochemistry

SG3PDH is a candidate vaccine for human schistosomiasisSix synthetic peptides were selected based on lowest homology to the human enzyme and named A , B1 , B , C , D and EImmunization of BALB / c mice with peptide A , B , C or E inducedweak cellular and humoral immune responses , whereas immunization with peptide B1 or D elicited strong immune responses that were protective to the challenge worms , not the hostTetrameric constructs containing 2 copies of 2 different peptides (D - MAP) greatly increased the immunogenicity of the peptides , Anti - D - MAP A - B immune responses were associated with significant (P < 005) decrease in worm and egg burdenD - MAP B1 - C caused no significant changes in challenge worm parametersImmunization with D - MAP D - E elicited increase in the challenge worm burden and decrease in worm fertilityThese results were discussed in relation to the variability in the nature and outcome of immune responses for each SG3PDH - derived peptide , and the neutralization of their often opposing effects in the D - MAP construct

Issued also as CD

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