TY - GEN AU - Rabab Kamel Mahmoud AU - Hussein Othman Ammar , AU - Mahmoud Mohamed Ghorab , AU - Soheir Abdallah Elnahhas , TI - Design of a transdermal delivery system for an analgesic drug / PY - 2008/// CY - Cairo : PB - Rabab Kamel Mahmoud , KW - Pain KW - Polymers KW - Tramadol N1 - Thesis (Ph.D.) - Cairo University - Faculty Of Pharmacy - Department Of Pharmaceutics; Issued also as CD N2 - Tramadol , a centrally - acting potent analgesic with weak opioid agonist activity (mainly M1 metabolite) and less side effects than other analgessics , has a half - life of 6hours , therefore , requires frequent dosing.It is freely soluble in water ; hence , judicious selection of retarding formulations is necessary UR - http://172.23.153.220/th.pdf ER -