Expression of the antiapoptotic gene survivin in acute leukemias /
دلالة الجين المثبط لموت الخلايا"السيرفيفين"فى اللوكيميات الحادة
Mona Hamed Ibrahim ; Supervised Hoda Sadek , Shadia Ragab , Nancy M. Elguindy
- Cairo : Mona Hamed Ibrahim , 2009
- 281P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
Acute leukemias are clonal expansions of uncommitted or partially comintted haematopietic precursor cells.Abnormalities in the control of programmed cell death(apoptosis) play an important role in leukemogenesis.Survivin is a member of Inhibitor of Apoptosis Proteins(IAP) family.Survivin prevents apoptosis by blocking caspase activity