Mona Mohamed Abdelhakim <br/><br/>
Vascular endothelial growth factor and her - 2 / neu in breast cancer /  
 دراسة عامل النمو الغشائى البطانى الوعائى والهير - 2 نيو فى حالات سرطان الثدي 
Mona Mohamed Abdelhakim ; Supervised Hamdy Mahmoud Hassaneen , Samar Kamal Kassim , Mohamed Ali Eldesoukey 
 - Cairo :   Mona Mohamed Abdelhakim ,   2004 
 - 167P :   ill ;   30cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty Of Science - Department Of Biochemistry 
<br/><br/> Breast cancer represents an important problem in Women oncology A growing tumor induces the host endothelial cells to proliferate and supply the requisite vascular support allowing tumor development Vascular endothelial growth factor (VEGF) and HER2 - neu have been demonstrated to induce angiogenesis in epithelial tumors , this study included 45 tumors from patients with breast cancer in different grades and stages , in addition to 18 samples of benign breast lesions VEGF has been measured in the cytosolic fractions using enzyme immunoassay Tissue HER2 - neu was assessed using immunohistochemistry for its protein VEGF mean rank was significantly higher in breast cancer tumors compared to benign lesions (P=0001) Eleven samples were positive for Her2 - neu of them were in malignant group , with highest frequency in grade (IIIII) of the disease (11 / 45 , 25 
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<br/><br/><label>Subjects--Index Terms: </label>HER2 - neu VEGF