TY  - BOOK
AU  - Shimaa Mahmoud Abobakr Mahmoud,
AU  - Olfat Gamil Shaker 
AU  - Mohamed Tharwat Hegazy 
AU  - Ayman Mohamed Hany Shehata 
TI  - Possible role of lncRNA MEG3, lncRNA MAFG-AS1 on miRNA 147 in pathogenesis of Behcet’s disease
U1  - 612.814 
PY  - 2024///
KW  - Medical Biochemistry
KW  - qrmak
KW  - Behcet’s disease
KW  - lncRNA MEG3
KW  - lncRNA MAFG-AS1
KW  - miRNA147
N1  - Thesis (Ph.D)-Cairo University, 2023; Bibliography: pages 79-103.; Issues also as CD
N2  - Background .Behcet disease (BD) is an autoinflammatory disease characterized by a triad of uveitis, oral and genital aphthae, and described to have altered Toll-like receptors (TLR) on macrophages. It is diagnosed clinically due to the unavailability of any pathognomonic test. If left untreated, it can lead to disability, so early diagnosis and proper management are a must to restrain the inflammation. LncRNA MEG3 and lncRNA MAFG-AS1 are regulators of miRNA 147, induced upon TLR stimulation. Our study suggested them to be possible new biomarkers for BD. However, this needs to be investigated in future in vivo and in vitro studies.
Subjects and methodology
The participants in this study were 100 Egyptian adults who were classified into two groups: fifty BD patients, and fifty age and sex-matched controls. Real- time PCR was used to measure the expression levels of serum LncRNA MEG3, lncRNA MAFG-AS1, and miRNA 147.
Results
LncRNA MEG3 and lncRNA MAFG-AS1 were significantly downregulated in the serum of our BD patients. While serum miRNA 147 was significantly upregulated in BD patients.
Conclusions
It can be concluded that lncRNA MEG3, lncRNA MAFG-AS1, and miRNA147 are promising diagnostic markers and therapeutic targets for BD patients; مرض بهجت هو مرض ذاتي المناعة يتميزبوجود قرح بالفم والأعضاء التناسلية والتهاب بالعين. يوصف بوجود متغيرات TLR   علي الخلايا الأكلة الكبيرة. يتم تشخيصه اكلينيكيا لغياب اختبار مميز له. أذا تم تركه دون علاج يؤدى الى اعاقة لذلك سرعة التشخيص والعلاج ضرورة للحد من الإلتهاب . الرنا  الطويل الغير مكود MEG3  والرنا الطويل الغير مكود MAFG-AS1 منظمين للرنا الصغير 147 الذى ينتج عن اثارة TLR.  دراستنا تقترحهم كوسيلة جديدة  لتشخيص  مرض بهجت
ER  -