TY  - BOOK
AU  - Manar Ahmed Abdel Aziz Mansi,
AU  - Hala Essam Eldin Mohamed Kahla
AU  - Aamal Ahmed Mohamed
AU  - Rasha Sobh Mohamed
AU  - Yasmin Abdel Fattah Mohamed
TI  - Impact of RAGE gene polymorphism in patients with type 2 diabetes complicated with diabetic nephropathy
U1  - 616.466 
PY  - 2024///
KW  - diabetic
KW  - qrmak
KW  - Receptor for advanced glycated end products (RAGE)
KW  - Gene  polymorphism
KW  - Type 2 diabetes mellitus (T2DM)
KW  - Single nucleotide  polymorphism (SNP)
N1  - Thesis (Ph.D)-Cairo University, 2024.; Bibliography: pages 200-250; Issued also as CD
N2  - The development of genetic biomarkers in different chronic diseases has 
focused on assisting in diagnosis and monitoring disease complications. 
Receptor for advanced glycated end products (RAGE) gene 
polymorphism has been implicated previously in type 2 diabetes mellitus 
pathophysiology and its complications, particularly diabetic nephropathy. 
Objective: To assess single nucleotide polymorphism (SNP) of RAGE 
gene at rs 1800625 (-429 T> C) among type 2 diabetic patients and to 
investigate the relationship between this polymorphism and diabetic 
nephropathy. 
Methods: In a case control analytical study including 370 subjects; 185 
T2DM patients complicated with nephropathy and 185 T2DM patients 
without nephropathy as control subjects. All T2DM patients were 
subjected to assessment of nephropathy according to ACR, serum 
creatinine and e-GFR and assessment of gene polymorphism at rs 
1800625 (-429T > C). 
Outcome measures: to assess the relation between RAGE gene 
polymorphism and Diabetic nephropathy in T2DM. 
Results: there was no significant difference between the 2 groups of our 
study (T2DM with and without nephropathy) regarding Allelic 
discrimination of RAGE gene at rs 1800625 (-429T > C). Also, there 
was no statistically significant relation between ACR, e-GFR, serum 
creatinine, FBS, HBA1C and allelic discrimination of RAGE gene at 
rs1800625 -429 T > C. 
Conclusion: There was no association between rage gene polymorphism 
at rs 1800625 (-429T > C) and diabetic nephropathy in type 2 diabetes 
mellitus; الهدف من هذه الدراسة هو الكشف عن تعدد أشكال أحادي النوكليوتيداتSNP)) في جين RAGE  عند rs1800624 في مرضى السكري من النوع 2 وعلاقته باعتلال الكلى السكري. أجريت دراسة الحالة والشواهد هذه على 370 مريضًا بالسكري من النوع 2 مصاب أو غير مصاب  باعتلال الكلى السكري (185 مريضا في كل مجموعة).
النتائج: لم يكن هناك فرق كبير بين مجموعتين من دراستنا (T2DM مصاب أو غير مصاب باعتلال الكلى) من حيث تعدد الأشكال لجين الـ RAGE عند rs 1800625 (-429T>C).
وعليه استنتجنا أنه لا يوجد ارتباط بين تعدد أشكال جين الـRAGE عند rs 1800625  -429T>C واعتلال الكلى السكري في داء السكري من النوع 2

ER  -