TY - GEN AU - Amira ELHam Fares AU - Hala SalahELDin Zaatar , AU - Tarek Ahed Essawy , TI - Oral soft tissue reaction against apexit a calcium hydroxide based sealer and endofill a zinc oxide eugenol based sealer in the rat : : Histological , histochemical and studies / PY - 2006/// CY - Cairo : PB - Amira ELHam Fares , KW - Apexit KW - Buccal KW - Endofill KW - Oral KW - Rat N1 - Thesis (M.Sc.) - Cairo University - Faculty Of Oral and Dental Medicine - Department Of Oral Biology; Issued also as CD N2 - Most root canal sealers in common use contain zinc oxide as the base ingredient , whereas the liquid component is eugenolEugenol when applied to soft tissues or to cells in culture has markedly toxic effectsTopical application of eugenol on rat labial mucosa can cause cell necrosisEugenol also inhibits prostaglandin synthesis , cell respiration and mitochondrial activityIt also causes a changes in enzyme activity and alteration of the cell membrane UR - http://172.23.153.220/th.pdf ER -