Tayseer Mohamed Abdelrazek Elnawawy  <br/><br/>
A pharmaceutical study on formulation of an antihypertensive drug in controlled release systems /  
 دراسة صيدلية على صياغة احد عقاقير ضغط الدم المرتفع على هيئة انظمة ممتدة المفعول 
Tayseer Mohamed Abdelrazek Elnawawy ; Supervised Samia Abdelkader Nour , Dalia M. Ghorab , Abdelmonaem Swailam 
 - Cairo :   Tayseer Mohamed Abdelrazek Elnawawy ,   2009 
 - 147 P. :   charts ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics 
<br/><br/> Formulation of gastroretentive dosage forms is a step toward improving the bioavailability of the drug tested. In order to control its release, diltiazem hydrochloride (highly soluble drug) was formulated as effervescent floating granules prepared using different polymers like eudragit S100, L100, RS100,RL100, in D/P ratio 1:3, 1:5 and 1:7, Also 1:1 1:3, 1:5 and 1:7 were the D/P ratios used for granules prepared using ethylcellulose and lipophilic matrices as: beeswax and carnauba wax 
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<br/><br/><label>Subjects--Index Terms: </label>Diltiazem hydrochloride Effervescent floating granules  Gastroretentive dosage forms