TY - BOOK AU - Tayseer Mohamed Abdelrazek Elnawawy AU - Abdelmonaem Swailam , AU - Dalia Mahmoud Ghorab , AU - Samia Abdelkader Nour , TI - A pharmaceutical study on formulation of an antihypertensive drug in controlled release systems / PY - 2009/// CY - Cairo : PB - Tayseer Mohamed Abdelrazek Elnawawy , KW - Diltiazem hydrochloride KW - Effervescent floating granules KW - Gastroretentive dosage forms N1 - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics; Issued also as CD N2 - Formulation of gastroretentive dosage forms is a step toward improving the bioavailability of the drug tested. In order to control its release, diltiazem hydrochloride (highly soluble drug) was formulated as effervescent floating granules prepared using different polymers like eudragit S100, L100, RS100,RL100, in D/P ratio 1:3, 1:5 and 1:7, Also 1:1 1:3, 1:5 and 1:7 were the D/P ratios used for granules prepared using ethylcellulose and lipophilic matrices as: beeswax and carnauba wax UR - http://172.23.153.220/th.pdf ER -