Abdallah Mohamed Gamil Abdallah  <br/><br/>
Cancer epigenetics from basic biology to molecular targeted therapy /  
 ما حول العوامل الجينية للسرطان من الاسس الحيوية الى العلاجات الجزيئية الاستهدافية 
Abdallah Mohamed Gamil Abdallah ; Superivsed Iman Maher Mansour , Gamal Thabet Ali Ebid 
 - Cairo :   Abdallah Mohamed Gamil Abdallah ,   2009 
 - 182P. :   facsimiles ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology 
<br/><br/> Epigenetics refers to the study of heritable changes in gene expression that occur without a change in DNA sequence . DNA methylation and histone modification ( methylation acetylation deacetation and phosphorylation ) are epigenetic mechanisms which regulate gene expression . DNA methylation down- regulates gene activity while modification of the histone can be carried out multiple mechanisms leading to either the upregulation or down- regulation of the associated gene 
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<br/><br/><label>Subjects--Index Terms: </label>Cancer epigenetics DNA methylation Histone modification bisulfite modification