TY - BOOK AU - Abdallah Mohamed Gamil Abdallah AU - Gamal Thabet Ali Ebid , AU - Iman Maher Mansour , TI - Cancer epigenetics from basic biology to molecular targeted therapy / PY - 2009/// CY - Cairo : PB - Abdallah Mohamed Gamil Abdallah , KW - Cancer epigenetics KW - DNA methylation KW - Histone modification bisulfite modification N1 - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology; Issued also as CD N2 - Epigenetics refers to the study of heritable changes in gene expression that occur without a change in DNA sequence . DNA methylation and histone modification ( methylation acetylation deacetation and phosphorylation ) are epigenetic mechanisms which regulate gene expression . DNA methylation down- regulates gene activity while modification of the histone can be carried out multiple mechanisms leading to either the upregulation or down- regulation of the associated gene ER -