TY - GEN AU - Nevein Farouk Francis AU - Azza Mahmoud Kamel , AU - Nasr Mohamed Ali , AU - Thoraya Mohamed Abd El hamid , TI - Fludarabine and Cyclophosphamide Versus COP As First Line Treatment In Chronic Lymphocytic Leukemia Patients / PY - 2006/// CY - Cairo : PB - Nevein Farouk Francis , KW - Chronic lymphocytic leukemia KW - fludarabine - COP N1 - Thesis (PH.D.) - Cairo University - National Cancer Institute - Department Of Oncology; Issued also as CD N2 - Chronic lymphocytic leukemia (CLL) is a neoplastic disease characterized by the accumulation of small mature appearing lymphocytes in the blood , marrow , and lymphoid tissues with the introduction of new therapies and novel combination approaches , the therapeutic goal of CLL has shifted to that of achieving a molecular complete response by eradicating all malignant B cells and therefore , residual disease especially in younger patients ER -