TY - GEN AU - Zainab Ali Hassan AU - Hala Gabr Metwally , AU - Iman Ali Attia , AU - Tayssir Kamel Eyada , TI - Generation of Dendritic Cells from Acute Myeloid Leukemic Blasts Using IL - 4 and GM - CSF / PY - 2006/// CY - Cairo : PB - Zainab Ali Hassan , KW - AML KW - APCs KW - Dendritic cells N1 - Thesis (PH.D.) - Cairo University - Faculty Of Medicine - Department Of Clinical and Chemical Pathology; Issued also as CD N2 - Effective presentation of tumor antigens is fundamental to strategies aimed at enrolling the immune system in eradication of residual disease after conventional treatment Myeloid malignancies provide a unique opportunity to drive DCs functioning APCs from malignant cells themselves This study aimed at producing of DCs from AML blasts using IL - 4 and GM - CSF Sixteen cases out of 20 cases generated DCs from AML blasts using IL - 4 and GM - CSF with the highest change with IL - 4 The highest viability was with GM - CSF and the highest DCs count and morphologically differentiated DCs were with both cytokines ER -