Marwa Galal Eldin Elgazzar  <br/><br/>
Synthesis of new pyrrole pyrazole pyrimidine and pyrrolopyrimidine derivatives carrying a sulfonamide moiety of expected antitumor activity :  with studying the synergistic effect of y - irradiation /  
 تشييد مشتقات البيرول : البيرازول : البيريميدين والبيرولوبيريميدين الجديدة والتى تحتوى على مجموعة السلفوناميد المتوقع لها نشاطا كمضادلت للسرطان :   ودراسة التأثير التحفيزى للتشعيع الجامى 
Marwa Galal Eldin Elgazzar ; Supervised Fatma Abdelfattah Ragab , Mostafa Mohamed Soliman Ghorab , Helmi Ismail Heiba 
 - Cairo :   Marwa Galal Eldin Elgazzar ,   2010 
 - 164 P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry 
<br/><br/> In a search for new cytoloxic agents with improved antitumor activity some new pyrrole pyrazole pyrimidine and pyrrolo [2,3-d] pyrimidine derivatives bearing sulfonamide moiety were synthesized . All the newly synthesized compounds were subjected to in - vitro cytotoxic screening also the synergism of the synthesized compounds with radiation was studied . These new compounds were docked in the active site of the carbonic anhydrase enzyme 
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<br/><br/><label>Subjects--Index Terms: </label>Pyrazole  Pyrimidine  Sulfonamide