TY - BOOK AU - Sameh Hosam Eldin Abdelalim AU - Ahmed Abdelbary Abdelrahman , AU - Mohammed Shafik Elridy , TI - Study of the encapsulation of the antitubercular pyrazinamide in niosomes / PY - 2010/// CY - Cairo : PB - Sameh Hosam Eldin Abdelalim , KW - Niosomes KW - Pyrazinamide KW - Tuberculosis N1 - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics; Issued also as CD N2 - The work in this thesis involves formulation and characterization of pyrazinamide niosomal formulations aiming to increase the efficacy decrease the drug side effects and toxicity . Pyrazinamide niosomal were formulated using Span 60 and Span 85 along with cholsterol and charge inducing agents . Different factors affecting the entrapment of pyrazinamide in the perpared niosomes were studied including the effect of molar ratio surface chang and swelling time ER -