Islam Tariq Eddiasty <br/><br/>
Baclofen derivatives :   Structural parameters vs. receptor sffinities and physicochemical properties as predicted from BCS characteristics /  
Islam Tariq Eddiasty ; Supervised Hilde Spahn - Langguth , Laila G. Mahran , Raimund Niess 
 - Cairo :   Islam Tariq Eddiasty ,   2009 
 - 99 Leaves :   charts , facsimiles ;   30cm 
<br/><br/>Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry 
<br/><br/> Baclofen a specific (gamma amino - butyric acid ) GABA B receptor agonist has successfully been used for decades for the treatment of spastic movement especially in instances of spinal cord injury spastic diplegia and multiple sclerosis . On the other hand the drug suffers from poor availabililty at the site of action the CNS despite its excellent intestinal absorption