TY - BOOK AU - Safaa Gabarty Abdelwahed AU - Amal Abdelwahab Mohammed , AU - Ebtesam Mohammed Fareed , AU - Nehad Ahmed Mosaad , TI - Association of polymorphisms in receptor for advanced glycation end products gene with diabetic retinopathy / PY - 2010/// CY - Cairo : PB - Safaa Gabarty Abdelwahed , KW - Advanced glycation end products KW - Diabetic retinopathy KW - Receptor for advanced glycation end products N1 - Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology; Issued also as CD N2 - Diabetes mellitus is a disorder characterized by hyerglycemia due to an absolute or relative deficiency of insulin and or insulin resistance . Diabetes patients are prone to long- term complications such as retinoopathy cataract atherosclerosis neuropathy and nephropathy by increasing protein glycation and the gradual build - up of AGEs in body tissues and activation of the RAGE leading to a cascade of pro- imflammatory and pro- coagulant responses which are important in the pathogenesis of the vascular complications of diabetes ER -