Yasser Mabrouk Abdelwahhab Bakr

Study of the sensitivity of lung cancer cell lines to TRAIL - induced apoptosis / دراسة حساسية خلايا أورام الرئة المزروعة معمليا إلى الموت المبرمج المستحث ببروتين الترايل Yasser Mabrouk Abdelwahhab Bakr ; Supervised Mervat Elsayed Mohammed , Abdelhady Ali Abdelwahhab , Nadia Mohammed Elguendy - Cairo : Yasser Mabrouk Abdelwahhab Bakr , 2010 - 97 P. : charts , facsimiles ; 25cm

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry

Tumor necrosis factor related apoptosis - inducing ligand (TRAIL) is an apoptogenic cytokine with great tumor specificity and has been recently considered as the magic bullet in the treatment of cancer . Recently , TRAIL - DR4 and TRAIL - DR5 directed monoclonal antibodies showed anti - tumor effect against a panel of non - small cell lung cancer (NSCLC) cell lines in vitro with different levels of sensitivity to TRAIL - induced apoptosis



Bcl - 2 and p53 NSCLC TRAIL