Antifibrotic potential of a selective COX-2 inhibitor (celecoxib) and a synthetic PPAR y ligand (pioglitazone) on liver fibrosis in Rats /
التأثير المحتمل لمثبط كوكس ٢ الإنتقائى (سيليكوكسيب) و منشط ببار جاما الإصطناعي (بيوجليتازون) علي تليف الكبد في الجرذان
Noha Samir Abdellatif ; Supervised Ahmed Hussein Galal , Fatma Ahmed Elbatrawi , Essam Fouad Alalkamy
- Cairo : Noha Samir Abdellatif , 2011
- 154 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pharmacology
Chronic liver injury, independent of the cause, is generally associated with the accumulation of matrix proteins, a process referred to as fibrosis. Over the last decade liver fibrosis is no longer viewed as either passive or permanent but as a dynamic process and potential therapies continue to be identified. Hepatic stellate cells (HSCs) play a critical role in the fibrogenesis of liver, so they are the target cells of antifibrotic therapy