Balqees Saeed Ahmed Mohamed Hazaa <br/><br/>
A pharmaceutical study on some modified release solid dosage forms of certain statins /  
 دراسة صيدلية على بعض الأشكال الصيدلية الصلبة محورة الإنطلاق لستاتينات معينة 
Balqees Saeed Ahmed Mohamed Hazaa ; Supervised Ahmed Abdelbary Abdelrahman , Howida Kamal Ibrahim 
 - Cairo :   Balqees Saeed Ahmed Mohamed Hazaa ,   2011 
 - 188 P. :   charts ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics 
<br/><br/> Simvastatin is a potent inhibitor of 3- hydroxy - 3 - methy1 - glutary1 - coenzyme A ( HMG - CoA ) reductase and a cholesterol - lowering widely uaed to treat hypercholesterolemia . However, it gave poorly oral bioavailability ( < 5% ) due to its water - insolubility and extensive first pass metabolism by the CYP 450 isoform 3A4, and to a lesser degree, by CYP3A5, in the intestinal wall and liver 
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<br/><br/><label>Subjects--Index Terms: </label>Hypercholesterolemia  Orodispersible  Simvastain