TY  - BOOK
AU  - Balqees Saeed Ahmed Mohamed Hazaa
AU  - Ahmed Abdelbary Abdelrahman , 
AU  - Howida Kamal Ibrahim , 
TI  - A pharmaceutical study on some modified release solid dosage forms of certain statins / 
PY  - 2011///
CY  - Cairo : 
PB  - Balqees Saeed Ahmed Mohamed Hazaa , 
KW  - Hypercholesterolemia
KW  - Orodispersible
KW  - Simvastain
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics; Issued also as CD
N2  - Simvastatin is a potent inhibitor of 3- hydroxy - 3 - methy1 - glutary1 - coenzyme A ( HMG - CoA ) reductase and a cholesterol - lowering widely uaed to treat hypercholesterolemia . However, it gave poorly oral bioavailability ( < 5% ) due to its water - insolubility and extensive first pass metabolism by the CYP 450 isoform 3A4, and to a lesser degree, by CYP3A5, in the intestinal wall and liver
UR  - http://172.23.153.220/th.pdf
ER  -