Hany Ahmed Fouad Elghobary <br/><br/>
Methylation framework of cell cycle gene inhibitor p16 INK4A in hepatocellular carcinoma patients /  
 فى مرضى سرطان الخلايا الكبدية p16INK4A ميثلة الجين المثبط للدورة الخلوية جين ال 
Hany Ahmed Fouad Elghobary ; Supervised Fatma Ahmed Elmougy , Nabil Mostafa Khalil Elkady , Sahar Abdelatty Sharaf 
 - Cairo :   Hany Ahmed Fouad Elghobary ,   2012 
 - 168P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology 
<br/><br/> Hepatocellular carcinoma ( HCC ) is currently the fifth most common solid tumor worldwide and the third leading cause of cancer related death . The tumor suppressor gene p16 INK4A is located on chromosome 9p21 and encodes the p16 protein , which binds selectively to CDK4 to inhibit activation of the CDK4 / cyclin D complex in the G1 phase . Inactivation of this gene which normally inhibits progression to the G1 phase of the cell cycle is involved in the initiation of tumors 
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<br/><br/><label>Subjects--Index Terms: </label>Cell cycle gene  Hepatocellular  p16 INK4A