TY  - BOOK
AU  - Hany Ahmed Fouad Elghobary
AU  - Fatma Ahmed Elmougy , 
AU  - Nabil Mostafa Khalil Elkady , 
AU  - Sahar Abdelatty Sharaf , 
TI  - Methylation framework of cell cycle gene inhibitor p16 INK4A in hepatocellular carcinoma patients / 
PY  - 2012///
CY  - Cairo : 
PB  - Hany Ahmed Fouad Elghobary , 
KW  - Cell cycle gene
KW  - Hepatocellular
KW  - p16 INK4A
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology; Issued also as CD
N2  - Hepatocellular carcinoma ( HCC ) is currently the fifth most common solid tumor worldwide and the third leading cause of cancer related death . The tumor suppressor gene p16 INK4A is located on chromosome 9p21 and encodes the p16 protein , which binds selectively to CDK4 to inhibit activation of the CDK4 / cyclin D complex in the G1 phase . Inactivation of this gene which normally inhibits progression to the G1 phase of the cell cycle is involved in the initiation of tumors
ER  -