Sherif Mofeed Megalla Ekladious <br/><br/>
Real - time PCR assay of VKORC1 and CYP2C9 gene polymorphisms that affect warfarin response /  
  استخدام تفاعل البلمرة المتسلسل فى الزمن الحقيقى لاكتشاف الأشكال الجينية للجين CYP2C9والجينVKORC1 اللذان يؤثران على الاستجابة لدواء الوارفارين   
Sherif Mofeed Megalla Ekladious ; Supervised Hazem Elsayed Abouyoussef , Sahar Abdelatty Sharaf , Marianne Samir Makboul 
 - Cairo :   Sherif Mofeed Megalla Ekladious ,   2012 
 - 127P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology 
<br/><br/> Warfarin is a commonly used oral anticoagulant with a narrow therapeutic index and various genetic and clinical factors that influence interpatient variability in dose requirements . This study investigated the impact of genetic and nongenetic factors on warfarin dose requirements in Egyptians . DNA was extracted from 50 patients taking warfarin for more than 1 year and genotyped for VKORC1 (1173 C> T) , CYP2C9 *3 (1075 C>)gene polymorphisms using SYBR Green - based multiplex allele - specific PCR 
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<br/><br/><label>Subjects--Index Terms: </label>CYP2C9  VKORC1  Warfarin