Synthesis and pharmacological screening of some fused pyrimidine derivatives /
تشييد و فحص الفاعلية الفارماكولوجية لبعض مشتقات البيريمدين المكثفة
Mai Saeed Mohamed Nour ; Supervised Nehad AbouElmagd Elsayed , Reem Khidr Arafa
- Cairo : Mai Saeed Mohamed Nour , 2012
- 130 P. : facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry
Cancer is a large, heterogeneous class of diseases in which a group of cells exhibit uncontrolled growth. It could be managed via several mechanisms of actions as antifolates, heat shock protein inhibitors and signal transduction inhibitors. Many literature reports have showed that pyrimidines and fused ptrimidines can display an anticancer activity through one or more of the above listed modes of action