TY - BOOK AU - Sara Shaban Ibrahim Mohamed AU - Hanan Mohamed Refaat , AU - Helmy Imail Heiba , AU - Mohamed Abdelrahman Shaaban , TI - Synthesis of new thiazole derivatives bearing a sulfonamide moiety of expected anticancer and radiosensitizing activities / PY - 2012/// CY - Cairo : PB - Sara Shaban Ibrahim Mohamed , KW - Anticancer KW - Sulfonamide KW - Thiazole N1 - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry; Issued also as CD N2 - In a search for new cytotoxic agents with improved antitumor activity and selectivity , some new pyranothiazole and thiazolopyranopyimidine derivatives bearing sulfonamide moiety were synthesized . The newly synthesized compounds were evaluated for their antitumor activity alone and in combination with y - irradiation . These new compounds were docked inside the active site of carbonic anhydrase II to predict their mechanism of action UR - http://172.23.153.220/th.pdf ER -