Mostafa Galal Eldin Elgazzar

Synthesis of some novel quinoxaline benzenesulfonamide derivatives with expected anticancer activity with studying the synergistic effect of gamma irradiation / تشييد و تحضير بعض مشتقات الكينوكزالين الجديدة و التى تحتوى على مجموعة السلفوناميد ذات التأثير المحتمل كمضادات للسرطان و دراسة التأثير التحفيزى للتشعيع الجامى Mostafa Galal Eldin Elgazzar ; Supervised Fatma Abdelfattah Ragab , Mostafa Mohamed Soliman Ghorab - Cairo : Mostafa Galal Eldin Elgazzar , 2012 - 135 P. : charts , facsimiles ; 25cm

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

The present work deals with the synthesis of some new sulfaquinoxaline derivatives in which the 4-amino group was replaced by different pharmacophoric groups as thioureido, thiourethane or different hetarocycles. The key starting compound for the synthesis of the target compounds is 4 isothiocyanato-N-quinoxalin-2-yl-benzenesulfonamide from which 26 new compounds were synthesized and their elemental analysis and spectral data (IR, ₁H-NMR, ₁₃C-NMR and mass spectroscopy) were illustrated and discussed



Anticancer Quinaxuline Sulphonomide