TY - BOOK AU - Mayada Elhadi Babiker Ahmed AU - Mahmoud Mohamed Ghorab , TI - Formulation and biopharmaceutical evaluation of anti-acne drug in a pharmaceutical form / PY - 2012/// CY - Cairo : PB - Mayada Elhadi Babiker Ahmed , KW - HP-Ý-CD KW - Isotretinoin KW - Surfactant enriched tablets N1 - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics; Issued also as CD N2 - Isotretinoin (13-cis-retinoic acid) is a poor water- soluble drugs commonly used in the treatment of severe cases of acne. The aim of this project is formulate isotretinoin in form of tablet and enhance its solubility and dissolution rate by the use of formulations containing either surfactant (SlS and Tweeen 20) or HP-Ý-CD.The critical micelle concentration for each surfactant was determined ER -