Mohammed Weam Ahmed <br/><br/>
Modulating the balance between COX2 and PDE5 inhibitory activities of celecoxib analogues by adapting the nature of the core ring and peripheral rings substitution /  
 تحوير التوازن التثبيطى لعقار السيليكوكسيب لانزيمى الكوكس - 2 والفو سفودايستراز - 5 عن طريق تكييف طبيعة الحلقة الأساسية ومستبدلات الحلقات الطرفية 
Mohammed Weam Ahmed ; Supervised Ashraf H. Abadi , Raimund Niess 
 - Cairo :   Mohammed Weam Ahmed ,   2011 
 - 71Leaves :   charts , facsimiles ;   30cm 
<br/><br/>Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry 
<br/><br/> The identification and characterization of inducible form of cyclooxygenase (COX2) in inflammatory cells in the early 1990s were the start of a race to the development of more selective nonsteroidal anti - inflammatory drugs (NSAIDs) , collectively known as coxibs , with reduced gastric - and nephrotoxicity compared to classical NSAIDs . However , coxibs were reported to increase the incidence of systemic hypertension and thromboembolic complications including myocardial infarction