TY  - BOOK
AU  - Mohammed Weam Ahmed
AU  - Ashraf Mostafa Abadi , 
AU  - Raimund Niess , 
TI  - Modulating the balance between COX2 and PDE5 inhibitory activities of celecoxib analogues by adapting the nature of the core ring and peripheral rings substitution / 
PY  - 2011///
CY  - Cairo : 
PB  - Mohammed Weam Ahmed , 
N1  - Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
N2  - The identification and characterization of inducible form of cyclooxygenase (COX2) in inflammatory cells in the early 1990s were the start of a race to the development of more selective nonsteroidal anti - inflammatory drugs (NSAIDs) , collectively known as coxibs , with reduced gastric - and nephrotoxicity compared to classical NSAIDs . However , coxibs were reported to increase the incidence of systemic hypertension and thromboembolic complications including myocardial infarction
UR  - http://172.23.153.220/th.pdf
ER  -