TY  - BOOK
AU  - Rasha Mahmoud Hassan Rashied
AU  - Ashraf H. Abadi , 
AU  - Raimund Niess , 
TI  - Design of novel diarylheterocycles with potential kinase inhibitory and anticancer properties / 
PY  - 2011///
CY  - Cairo : 
PB  - Rasha Mahmoud Hassan Rashied , 
N1  - Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
N2  - Previsouly reported , structurally diverse p38Ü MAP kinase inhibitors like pyridinyl-imidazole SB-203580 very often bind efficiently to their target , but suffer from potential toxicity due to the chelation of iron in cytochrome P450 by the imidazole or the pyridine ring which may result in hepatotoxicity and CNS adverse effects. Herein , we report the synthesis of novel 4,6-diaryl-2-oxo-( imino )-1,2-dihydropyridine-3-carbonitrile derivatives by multi-component reactions
UR  - http://172.23.153.220/th.pdf
ER  -