Amal Hassan Ali Hassan <br/><br/>
Structure-based design and synthesis of novel Ý-carboline derivatives and their biological evaluation as phosphodiesterase 5 inhibitors and anticancer agents /  
 التصميم القائم على الهيكل و تشييد مشتقات جديدة من البيتا كاربولين و تقييمهم الأحياني كمثبطات لإنزيم فوسفوداي إستريز ٥ و كعوامل مضادة للسرطان 
Amal Hassan Ali Hassan ; Supervised Ashraf H. Abadi , Nermin Salah Ahmed 
 - Cairo :   Amal Hassan Ali Hassan ,   2011 
 - 98 Leaves :   facsimiles ;   30cm 
<br/><br/>Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry 
<br/><br/> Tadalafil, a Ý-carboline derivatives that has been introduced to the market for treatment of Male Erectile Dysfunction, acts through inhibition of Phosphodiesterase 5, leading to elevation of cGMP, vascular relaxation in the corpora cavernosa and penile erection during sexual stimulation. The safety, tolerability of PDE5 inhibition as well as the involvement of cGMP as a key component in itracellular signaling may provide new therapeutic applications for this class of drugs