Shreen Mohamad Elnashar <br/><br/>
Design and synthesis of novel tetrahydro Ý-carboline derivatives and their biological evaluation as phosphodiesterase 5 inhibitors and apoptotic agents /  
Shreen Mohamad Elnashar ; Supervised Ashraf H. Abadi , Nermin S. Ahmed 
 - Cairo :   Shreen Mohamad Elnashar ,   2011 
 - 91 Leaves :   facsimiles ;   30cm 
<br/><br/>Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry 
<br/><br/> Recently, many studies and researches are carried out to study PDE5 and its inhibitors due to their promising therapeutic uses. PDE5 has been successfully targeted for treatment of male erectile dysfunction. The success of sildenafil (Viagra®), vardenafil (Levitra®) and tadalafil (Cialis®) in this regard has renewed interest in PDE5 as potential pharmacological targets