Salma Nabil Tammam <br/><br/>
Application of biodegradable nanopartieles in liver targeting of tacrolimus /  
Salma Nabil Tammam ; Supervised Nagia Nagib Afifi , Ola Heikal 
 - Cairo :   Salma Nabil Tammam ,   2010 
 - 163 Leaves :   charts , facsimiles ;   30cm 
<br/><br/>Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research  - Department of Pharmaceutical Technology 
<br/><br/> Tacrolimus is a potent immunosuppressant used in liver transplantation to avoid graft rejection. Tacrolimus has a narrow therapeutic index and exhibits variable phamacokinetics with high inter and intra-patient variability making dose adjustment and therapeutic drug monitoring a complicated task, not to mention increasing the occurrence of adverse effects