Stromal cell-derived factor-1 chemokine gene variant in myeloid leukemias /
دراسة التحور فى التركيب الجيني لجين العامل الخلوى الاساسى فى حالات سرطانات الدم الميلودية
Salwa Mahmoud Hussien ; Supervised Hoda Mohamed Abdelghany , Zainab Ali Hassan Elsaadany , Noha Yehia Ibrahim
- Cairo : Salwa Mahmoud Hussien , 2012
- 160 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
Both acute and chronic myeloid leukemia are initiated and sustained by a small, self-renewing population of leukemic stem cells, which produce progeny consisting of a heterogeneous population of progenitor cells. CXCL12, a chemokine abundantly produced by the bone marrow microenvironment, and its receptor CXCR4 have crucial roles in malignant cell trafficking