TY - BOOK AU - Noha Tarek Moharned Elhusseiny Esh AU - Hanan Alhusseini Mohamed , AU - Mona Kamal Elghamrawy , AU - Rania Ahmed Zayed , TI - Impact of circulating erythrocyte - derived microparticles on coagulation activation in sickle cell disease / PY - 2013/// CY - Cairo : PB - Noha Tarek Moharned Elhusseiny Esh , KW - Coagulation activation KW - D-dimer KW - Erythrocyte - derived microparticles N1 - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology; Issued also as CD N2 - Background: Sickle cell disease (SCD) is characterized by a hypercoagulable state as a result of multiple factors including chronic hemolysis and the presence of circulating cell- derived microparticles (MPs) . The cellular origin of such MPs and the exact mechanism by which it enhance coagulation in SCD are not fully understood . The study aimed to clarify the presence of circulating erythrocyte - derived MPs in SCD patients during painful crisis and in steady state and the impact of these MPs on coagulation activation and fibrinolysis ER -