TY - BOOK AU - Alice Saber Gerges AU - Eman Elghroury , AU - Inas Ismail Raafat , AU - Mai Mahmoud Sherif , TI - Glypican 3 as a novel marker for Hepatocellular carcinoma / PY - 2013/// CY - Cairo : PB - Alice Saber Gerges , KW - Glypican 3 KW - Hepatocellular carcinoma KW - Real time PCR N1 - Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology; Issued also as CD N2 - Most of patients with HCC are diagnosed at a late stage. Therefore, the prognosis of HCC patients is generally very poor. Alpha.fetoprotein has been widelly used , but its sensitivity has not been satisfactory , in addition to its non-specific elevation innon malignant hepatic diseases. Glypican 3, this protein(GPC3) is over-expressed in HCC, and not in normal hepatocytes and non-malignant liver disease ER -