Mai Muhammed Ragab <br/><br/>
Protein kinase R (PKR) expression as a predictive factor for interferon response in chronic hepatitis C patients /  
 نسبة وجود جين بروتين كايناز كدليل على مدى استجابة مرضى الالتهاب الكبدى الوبائى المزمن سى للعلاج بالانترفيرون 
Mai Muhammed Ragab ; Supervised Magdy Ali Amin , Amal Ahmed Mohamed 
 - Cairo :   Mai Muhammed Ragab ,   2013 
 - 99 P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology 
<br/><br/> Egypt has the highest prevalence of hepatitis C virus (HCV) worldwide . Currently combined pegylated interferon and ribavirin therapy are the standard treatment . The biological activity of interferon (IFN) is mediated by the induction of intracellular antiviral proteins, such as 2'-5' oligoadenylate synthetase, and dsRNA - activated protein kinase. IFN inducible double - stranded  RNA- activated protein kinase (PKR) is thought to play a key antiviral role against HCV 
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<br/><br/><label>Subjects--Index Terms: </label>Chronic hepatitis C Pegylated interfern  Protein kinase gene