TY - BOOK AU - Mai Muhammed Ragab AU - Amal Ahmed Mohamed , AU - Magdy Ali Amin , TI - Protein kinase R (PKR) expression as a predictive factor for interferon response in chronic hepatitis C patients / PY - 2013/// CY - Cairo : PB - Mai Muhammed Ragab , KW - Chronic hepatitis C KW - Pegylated interfern KW - Protein kinase gene N1 - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology; Issued also as CD N2 - Egypt has the highest prevalence of hepatitis C virus (HCV) worldwide . Currently combined pegylated interferon and ribavirin therapy are the standard treatment . The biological activity of interferon (IFN) is mediated by the induction of intracellular antiviral proteins, such as 2'-5' oligoadenylate synthetase, and dsRNA - activated protein kinase. IFN inducible double - stranded RNA- activated protein kinase (PKR) is thought to play a key antiviral role against HCV ER -