TY - BOOK AU - Nourhan Mohamed Diaa Eldien Abushahba AU - Alice Kamal Abdelaleem , AU - Magda Mohamed Noshy , TI - Role of basic fibroblast growth factor in suppressing senescence of human bone marrow- derived mesenchymal stem cells / PY - 2012/// CY - Cairo : PB - Nourhan Mohamed Diaa Eldien Abushahba , KW - Basic fibroblast growth factor KW - Bone marrow- derived MSCs KW - Cellular senescence N1 - Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology; Issued also as CD N2 - Mesenchymal stem cells (MSCs) have a limited lifespan in vitro . After a definite number of cell divisions MSCs enter a senescence phase where they undergo cell growth arrest and can be no longer used in therapeutic applications . Basic fibroblast growth factor (bFGF) is a growth factor that has the capability to maintain MSCs cells in an immature state and enhances their growth during in vitro expansion ER -