Hanaa Almelhuda Abdelwajed <br/><br/>
Detection of expansion of CD4⁺ CD28⁻ T cells in patients with rheumatoid arthritis by flow cytometry /  
  فى مرضى التهاب المفاصل الرثيانى باستخدام جهاز التدفق الخلوى (CD٤⁺ CD⁻)  تحديد مدى انتشار الخلايا الليمفاوية التوتية فئة 
Hanaa Almelhuda Abdelwajed ; Supervised Mervat Saad Elansary , Esmat Mohamed Elhusseiny , Nancy M. Elguindy 
 - Cairo :   Hanaa Almelhuda Abdelwajed ,   2013 
 - 116 P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology 
<br/><br/> Clonal expansion of CD4⁺ CD28⁻ T cells is a characteristic finding in patients with rheumatoid arthritis CD4⁺CD28⁻ T cells are oligoclonal lymphocytes that are rare in healthy individuals, but are found in high percentage in patients with rheumatoid arthritis . The presence of significant numbers of CD4⁺ CD28⁻ T cells could shift the immune response from B-cells activation and production of immunoglobulins toward activation of type-1  T helper cells and production of IFN-y and involvement of macrophages releasing matrix - degrading proteases 
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<br/><br/><label>Subjects--Index Terms: </label>CD4⁺ CD28⁻ T cells  Flow cytometry  Rheumatoid arthritis