TY - BOOK AU - Hanaa Almelhuda Abdelwajed AU - Esmat Mohamed Elhusseiny , AU - Mervat Saad Elansary , AU - Nancy M. Elguindy , TI - Detection of expansion of CD4⁺ CD28⁻ T cells in patients with rheumatoid arthritis by flow cytometry / PY - 2013/// CY - Cairo : PB - Hanaa Almelhuda Abdelwajed , KW - CD4⁺ CD28⁻ T cells KW - Flow cytometry KW - Rheumatoid arthritis N1 - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology; Issued also as CD N2 - Clonal expansion of CD4⁺ CD28⁻ T cells is a characteristic finding in patients with rheumatoid arthritis CD4⁺CD28⁻ T cells are oligoclonal lymphocytes that are rare in healthy individuals, but are found in high percentage in patients with rheumatoid arthritis . The presence of significant numbers of CD4⁺ CD28⁻ T cells could shift the immune response from B-cells activation and production of immunoglobulins toward activation of type-1 T helper cells and production of IFN-y and involvement of macrophages releasing matrix - degrading proteases UR - http://172.23.153.220/th.pdf ER -