Rania Mohamed Rahmo <br/><br/>
Pharmacological study of the possible antiulcerogenic effect of certain natural substances extracted from different medicinal plants /  
 دراسة دوائية للتأثير المضاد للقرحة المتوقع حدوثه باستعمال مواد طبيعية مستخلصة من بعض النباتات الطبية 
Rania Mohamed Rahmo ; Supervised Sanaa A. Kenawy , Laila G. Mahran , Dalaal M. Abdallah 
 - Cairo :   Rania Mohamed Fouad Rahmo ,   2013 
 - 159 P. :   charts , photographs ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology 
<br/><br/> A major clinical problem encountered with the use of indomethacin (IMN),a Non-steroidal anti-inflammatory drug, is gastrointestinal complications. It was reported that IMN develops gastropathy by inducing reactive oxygen species(ROS)as well as pro-inflammatory mediators such as tumor necrosis factor Ü (TNF-Ü). Moreover, IMN induced peptic ulcer (PU) by inducing apoptotic death, manifested by an increase in the expression of Cyt c and caspase-3 
<br/><br/>
<br/><br/><label>Subjects--Index Terms: </label>Indomethacin Peptic ulcer Reactive oxygen species