Effect of protein malnutrition on the metabolism of some anticancer drugs in the rat stomach /
تاثير سوء التغذية البروتينية على أيض بعض العقاقير المضادة للسرطان فى معدة الجرذان
Nancy Ahmed Nabil Shahin ; Supervised Tarek M. Kamal Motawi , Hanan M. Abdelgawad Hashim
- Cairo : Nancy Ahmed Nabil Shahin , 2013
- 147 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry
Aim of the work: the present study investigated the effect of protein malnutrition on the metabolism and toxicity of cisplatin (CP), 5-fluorouracil (FU) and mitomycin C (MMC) in rat stomach. Methods: weanling male wistar albino rats were fed normal (24%) or low (2.5%) protein diet for 28 days, and were allocated into eight group: a normally-fed control (N), a protein-malnourished control (PM), 3 normally-fed drug- treated groups (N-CP , PM-FU and N-MMC) and protien malnourished drug-treated group (PM-CP, PM-FU and PM-MMC)