TY - BOOK AU - Heba Allah Elsayed Abdelrhman AU - Ayman Mohamed Metwally , AU - Hussein Moustafa Khaled , AU - Ragia Hussein Badawy , TI - Prognostic significance of nucleophosmin gene (NPM1) mutations in acute myeloid leukemia / PY - 2013/// CY - Cairo : PB - Heba Allah Elsayed Abdelrhman , KW - Acute myeloid leukemia KW - NPM1 gene KW - Nucleophosmin gene N1 - Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology; Issued also as CD N2 - The remarkable molecular heterogeneity of acute myeloid leukemia (AML) has made a genetic - based classification, essential for accurate diagnosis, prognostic stratification, monitoring minimal residual disease, and developing targeted therapies. NPM1 mutations represent the most frequent alterations in AML, occurring in approximately one third of adult patients with AML, and are associated with a normal karyotype UR - http://172.23.153.220/th.pdf ER -