Noha Kamal Abdelmoamen <br/><br/>
Association between MDM2- SNP309 polymorphism and hepatocellular carcinoma in Egyptian patients with chronic viral hepatitis /  
  وسرطان الكبد فى المرضى المصايين بالالتهاب الكبدى الفيروسى المزمنMDM2- SNP309 العلاقة بين الطفرة الجنينية 
Noha Kamal Abdelmoamen ; Supervised Hebat Allah Mohamed Sharaf Eldeen , Afaf Ahmed Abdelelhady , Marianne Fathy Ishak 
 - Cairo :   Noha Kamal Abdelmoamen ,   2013 
 - 103 Leaves :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology 
<br/><br/> The murine double minute 2 (MDM2) an oncogene acts as a major regulator of the p53  protein . A polymorphism in the MDM2 promoter SNP309 (T/C) has been shown to alter protien expression and may thus play a role in carcinogenesis MDM2 is a nuclear phosphoprotien that binds to TP53 and inhibits TP53 - dependent transcription 
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<br/><br/><label>Subjects--Index Terms: </label>Chronic hepatitis and hepatocellular carcinoma  Egyptian patients MDM2- SNP309