Amro Hefnawy Mohamed Hefnawy <br/><br/>
Modulating celecoxib activity towards phosphodiesterase 5 inhibition rather than cyclooxygenase inhibition and evaluating its correlation to anticancer activity /  
 تحوير نشاط السيليكوكسيب باتجاه تثبيط الفوسفودايستراز ٥ بدلا من انزيمات الأكسدة الحلقية و ارتباط ذلك بالنشاط المضاد للسرطان 
Amro Hefnawy Mohamed Hefnawy ; Supervised Ashraf H. Abadi 
 - Cairo :   Amro Hefnawy Mohamed Hefnawy ,   2013 
 - 95 Leaves :   photographs ;   30cm 
<br/><br/>Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry 
<br/><br/> Selective COX-2 inhibitors were introduced as safer alternatives to NSAIDs with less gastrointestinal side effects. Celecoxib, Rofecoxib and valdecoxib were the most widely used COX-2 inhibitors. Unfortunately, it was found that the use of selective COX-2 inhibitors is associated with increased cardiovascular risk. By 2011, celecoxib was the only selective COX-2 inhibitors to remain available in the market as it showed better cardiovascular safety