Aya Zakaria Gamal Eldin Rashed <br/><br/>
Methylene blue decreases brain mitochondrial ABAD levels protecting mitochondrial function /  
Aya Zakaria Gamal Eldin Rashed ; Supervised Reham Mahmoud Abdelkader , Nabila Hamdi 
 - Cairo :   Aya Zakaria Gamal Eldin Rashed ,   2013 
 - 100 Leaves :   charts , photographs ;   30cm 
<br/><br/>Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmacology and Toxicology 
<br/><br/> Methylene blue (MB) is lately being proposed to be effective in treating alzheimer's disease (AD). Phase 2 clinical trials reported improvements in cognitive functions of AD patients after MB treatment. However, the exact mechanism of action of MB is still controversial and needs further investigations. Recently, the mitochondrial enzyme amyloid binding alcohol dehydrogenase (ABAD) has been shown to bind AŻ inducing mitochondrial dysfunction, providing a direct relation between AŻ and mitochondrial dysfunction occurring in AD